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Dipanjan Pan, Huck Chair in Nanomedicine and professor of material science and engineering as well as of nuclear engineering, has been appointed to serve as the Huck Institutes’ first director for innovation and entrepreneurship ecosystems. He brings an extensive track record of entrepreneurship to the role and will help other faculty members explore their options when it comes to commercializing research. Credit: Penn State. Creative Commons

Dipanjan Pan named Huck director for innovation and entrepreneurship ecosystems

Penn State’s Huck Institutes of the Life Sciences has named Dipanjan Pan, Dorothy Foehr Huck & J. Lloyd Huck Chair Professor in Nanomedicine and professor of materials science and engineering and of nuclear engineering, to serve as the Huck’s first director for innovation and entrepreneurship ecosystems.

Researchers have developed a new framework to study the functional impact of genetic background on the expression and severity of neurodevelopmental features associated with a deletion of a portion of chromosome 16. The research team used induced pluripotent stem cells (iPSC) derived from patients with the deletion, their families and a healthy donor that they differentiated into different types of neuronal cells — image shows immunostained iPSC-derived neurons on the left and iPSC-derived neural progenitor cells on the right — to study how interactions among a patient’s entire genetic architecture and the deletion help determine the features that the individual will manifest. Credit: Girirajan Laboratory / Penn State. Creative Commons

How can the same genetic mutation lead to different clinical outcomes?

Individuals that share the same deletion of a portion of chromosome 16 are at risk of developing neurodevelopmental disorders, but some experience severe intellectual disability or developmental delay, while others may only exhibit milder psychiatric features like depression or anxiety. How can this be? To answer this, a team led by Penn State scientists has developed methods to evaluate how genetic variants elsewhere in an individual’s genome work with the deletion to help determine the features that the individual will manifest.

Study first author Sohini Guha, postdoctoral scholar in the Department of Plant Science, in the greenhouse with plants in her experiment. Credit: Penn State. Creative Commons

Plant genes influence bacterial evolution in legume-bacteria partnership

In a recently published study, Penn State researchers described the complex relationship between plant host genes and rhizobial genes, and how plant genes strongly influence which rhizobial strains plants chose from a diverse mixture.

A handful of prunes has been shown to prevent bone loss over the course of a year in postmenopausal women, according to research by Mary Jane De Souza. Credit: Jaydyn Isiminger / Penn State. Creative Commons

Q&A: What should women do to keep their bones healthy?

One in 10 Americans experience osteoporosis, which significantly weakens bones and makes them more prone to fracture. Women comprise 80% of people with osteoporosis, and women approaching or in menopause are at the highest risk, according to Mary Jane De Souza, distinguished professor of kinesiology and physiology. De Souza explained that May serves as both Osteoporosis Awareness Month and Women’s Health Month, making it the ideal time for both women and men to learn how to maintain healthy bones for as long as possible.