News

After 30 years of research, Penn State startup reinvents the putting green

With professional golf season in full swing, David Huff, professor of turfgrass breeding and genetics at Penn State, says that seven out of the top 10 courses are using Poa, a type of grass that was once considered a weed — and his startup, PennPoa, is playing a critical role in making the grass the go-to seed for luxury courses.

RNA polymerase II transcription complexes were isolated directly from fruit fly embryos, preserving many of the proteins, DNA, RNA and nucleosomes present in the cell. Cryo-electron microscopy produced thousands of images and computational analysis sorted the imaging data into distinct groups to reconstruct multiple 3D-dimensional structures. The novel approach revealed that transcription complexes inside cells are not all identical, but instead exist in several structural forms. Credit: Courtesy of Katsuhiko Murakami / Penn State. Creative Commons

Messy life-producing cellular process caught in action for first time

Until recently, scientists had only witnessed the eukaryotic RNA at work in carefully assembled test tubes, stripped of the chaotic realities of life inside a cell. Now, a team led by Penn State researchers has captured a glimpse of this molecular machinery as it operates inside living organisms.

Facility director recognized for metabolomics work

Ashley Shay, director of the Metabolomics Core Facility at Penn State’s Huck Institutes of the Life Sciences, has been named the recipient of the Excellence in Metabolomics Support Award from the Early Career Members (ECM) group of the Metabolomics Association of North America (MANA).

The figure shows a photo of the team’s spheroids taken using immunofluorescence imaging, a type of microscopy that allows biologists to view specific proteins or molecules inside a cell or tissue. A total of 16 spheroids, although some are not visible in the figure, are positioned in a microgel structure using a specialized form of 3D printing. In their work, a team of researchers demonstrated that these spheroids can help support the formation of new blood vessels in regenerated bone tissue. Credit: Provided by Ibrahim Ozbolat/Daniel Hayes. All Rights Reserved.

Genetic ‘switches’ could program 3D-printed bone tissue for blood vessel growth

An interdisciplinary team of engineers and chemists at Penn State has laid the groundwork to 3D print spheroids — tiny clusters of living cells — capable of regenerating bone tissue in response to severe trauma or infections. By introducing different strands of genetic information into undifferentiated, commercially sourced stem cells, the team has demonstrated that bioprinting, which layers the fundamental building blocks of an organ tissue, can create cell clusters optimized to support bone tissue regeneration